针对“精准医疗”国家战略需求，面向“人民生命健康”，开发纳米孔新型单分子测序和早期诊断技术，实现基于纳米孔的基因测序仪器和癌症/肿瘤诊断装备，将精准医疗中心建成本领域内有一定影响力的单分子诊断技术研究中心，服务国家战略，提高人民健康水平。 

研究方向

纳米孔单分子检测及测序技术研究 

人才队伍

精准医疗研究中心现有成员19人，融合生物、物理、化学、自动化等学科，兼具理论与应用的交叉型研究队伍，其中研究员1人、副研究员8人、助理研究员8人、财务助理1人，海外留学人员11人。荣获省部级人才计划/项目14人次，其中中科院率先行动“百人计划”入选者1人次、“西部之光”入选者8人次、青年促进会会员3人，重庆市杰出青年1人次、重庆英才“创新创业领军人才”、“青年拔尖人才”各1人次。骨干成员兼任全国半导体设备与材料标准化技术委员会委员、中科院欧美同学会常务理事。  

研究成果

1.   Rui Zhu, Fupeng Qin, Xinchuan Zheng, Shaoxi Fang, Jianjun Ding, Deqiang Wang*, Liyuan Liang*. Single-molecule lipopolysaccharides identification and the interplay with biomolecules via nanopore readout. Biosens. Bioelectron., 2023, 240, 115641.  

2.   Zhong Wang, Fupeng Qin, Ji Wu, Wenhao Ma, Rongjie Li, Ting Weng, Bohua Yin, Liang Wang, Deqiang Wang*, Liyuan Liang*. Single-molecule recognition of Nucleolin and the interactions with DNA/RNA G-quadruplexes via nanopore decoding. Chem. Eng. J., 2023, 473, 145311.  

3.   Wanyi Xie, Shixuan He*, Shaoxi Fang, Rong Tian, Liyuan Liang, Deqiang Wang*. Phenylboronic acid-modified polyethyleneimine assisted neutral polysaccharide detection and weight-resolution analysis with a nanopipette. Nanoscale, 2023, 15, 7147-7153.  

4.   Mohamed Bahri, Shushay Hagos Gebre, Mohamed Amin Elaguech, Fekadu Tsegaye Dajan, Marshet Getaye Sendeku, Chaker Tlili*, Deqiang Wang*. Recent advances in chemical vapour deposition techniques for graphene-based nanoarchitectures: From synthesis to contemporary applications. Coord. Chem. Rev., 2023, 475, 214910.  

5.   Liyuan Liang*, Fupeng Qin, Sen Wang, Ji Wu, Rongjie Li, Zhong Wang, Meili Ren, Daixin Liu, Deqiang Wang*, Didier Astruc. Overview of the materials design and sensing strategies of nanopore devices. Coordination Chemistry Reviews, 2023, 478, 214998.  

6.   Yunjiao Wang, Zequn Wang, Liang Wang, Tianze Tong, Xiaoling Zhang, Shaoxi Fang, Wanyi Xie, Liyuan Liang, Bohua Yin, Jiahu Yuan*, Jin Zhang*, Deqiang Wang*. Comparison Study on Single Nucleotide Transport Phenomena in Carbon Nanotubes. Nano Lett., 2022, 22, 5, 2147-2154.  

7.   Ji Wu, Liyuan Liang*, Mingkun Zhang, Rui Zhu, Zhong Wang, Yajie Yin, Bohua Yin, Ting Weng, Shaoxi Fang, Wanyi Xie, Liang Wang, Deqiang Wang*. Single-Molecule Identification of the Conformations of Human C-Reactive Protein and Its Aptamer Complex with Solid-State Nanopores. ACS Appl. Mater. Interfaces, 2022, 14, 10, 12077-12088.  

8.   Wei Li, Yunjiao Wang, Yicen Xiao, Minghan Li, Qianshan Liu, Liyuan Liang, Wanyi Xie, Deqiang Wang*, Xiyun Guan*, Liang Wang*. Simultaneous Dual-Site Identification of 5^mC/8^oG in DNA Triplex Using a Nanopore Sensor. ACS Appl. Mater. Interfaces, 2022, 14, 29, 32948-32959.  

9.   Yexiang Liu, Xiaoling Zhang, Wanyi Xie, Shaoxi Fang, Bohua Yin, Daming Zhou, Jing Tang, Liyuan Liang, Wenqiang Lu, Shixuan He*, Deqiang Wang*. Cross Disjoint Mortise Confined Solid-State Nanopores for Single-Molecule Detection. ACS Appl. Nano Mater. 2021, 4, 9, 9811-9820.  

10.  Shixuan He, Rong Tian, Wei Wu, Wen-Di Li, Deqiang Wang*. Helium-ion-beam nanofabrication: extreme processes and applications. Int. J. Extrem. Manuf., 2021, 3, 012001.  

联系方式

陈雯琦 邮箱：chenwenqi@cigit.ac.cn 电话： (+86)-23-65935475