1.抗耐性新药研发；

2.基于外泌体的药物精准递送；

3.基于外泌体的精准检验新技术开发；

4.植物外泌体分离纯化材料及大规模提取技术开发。

2021年度中国科学院重庆绿色智能技术研究院优秀特别研究助理

1. XH Yang#, ZP Wang#, SC Xiang, DQ Wang, Y Zhao, D Luo, YF Qiu, C Huang, J Guo, YW Dai, SL Zhang*, Y He*. Optimization of the natural product Calothrixin A to discover novel dual Topoisomerase I and II inhibitors with improved anticancer activity[J]. J. Med. Chem, 2022, 65, 8040-8061.  

2. XH Yang#, BB Xie#, HB Peng#, GM Shi, J Guo, CH Wang*, Y He*. Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes[J]. J. Control. Release, 2021, 329, 454-467. 

3. XH Yang, JS Gao, J Guo, ZM Zhao, SL Zhang*, Y He*. Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative[J]. Life Sci, 2019, 219, 20-30.

4. XH Yang, GM Shi, J Guo, CH Wang*, Y He*. exosome-encapsulated antibiotic against intracellular infections of methicillin-resistant Staphylococcus aureus[J]. Int J Nanomed, 2018, 13, 8095-8104.

5. HB Peng, BB Xie, JJ Dai, YW Dai, XF Cen, XH Yang*, Y He*. Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar [5] arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus [J]. Mater. Chem. Front., 2022, 6, 360-367. 

6. GM Shi#, XH Yang#, JK Wang, WJ Wei, KC Hu, XY Huang, YF Qiu, Y He*. Isolation of extracellular outer membrane vesicles (OMVs) from Escherichia coli using EVscore47 beads. Molecules, 2024, 29(8), 1831. 

7. BB Xie#, XH Yang#, RX Zhang, J Guo, Z Chen, Y He*. Hollow and porous Fe3C-NC nanoballoons nanozymes for cancer cell H2O2 detection. Sensor Actuat B-Chem, 2021, 347, 130597. 

8. S Chen#, XH Yang#, Y Zhang, Y Liu, H Lu, Y Qiu, C Wang*. Inhalable porous microspheres loaded with metformin and docosahexaenoic acid suppress tumor metastasis by modulating premetastatic niche[J]. Mol Pharmaceutics, 2021, 18(7), 2622-2633. 

9. L Peng#, D Xu#, XH Yang#, JK Tang#, XL Feng*, S-L Zhang*, HL Yan*. Organocatalytic Asymmetric One-Step Desymmetrizing Dearomatization Reaction of Indoles: Development and Bioactivity Evaluation[J]. Angewandte Chemie, 2019, 131(1), 222-226 .

10. Q Liu#, XH Yang#, J Ji, S-L Zhang*, Y He*. Novel nannocystin A analogues as anticancer therapeutics: Synthesis, biological evaluations and structureeactivity relationship studies[J]. Eur J Med Chem, 2019, 170, 99-111. 

1. 国家自然科学基金青年基金, 病原菌靶向的仿生矿化外泌体介导化学-免疫联合疗法对抗胞内MRSA感染的研究, 2022/01-2024/12, 30万元, 主持

2. 重庆市自然科学基金面上项目, 新型天然产物Calothrixin B衍生物的合成、构效关系和作用机制研究, 2020/07-2023/06, 10万元, 主持

3. 企业委托项目, 生物体内STDM系列药物分析方法开发, 2020/12-2022/12, 75万元, 主持

4. 企业委托项目, EVS外泌体纯化分析方法开发,  2023/12-2024/12, 20万元, 主持